Nexium 40mg

Product Code: Nexium 40mg
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Active Ingredient: esomeprazole

Nexium is used for the treatment of gastroesophageal reflux disease (GERD).

Nexium as known as: Alenia, Alton, Asector, Axagon, Axiago, Ceso, Cronopep, Emep, Esmolac, Esofag, Esofag-d, Esomac, Esomep, Esomeprazol, Esomeprazolum, Esomezol, Esonix, Esopra, Esopral, Esopran, Esoprax, Esoprazol, Esoral, Esorest, Esotac,

Nexium

Brand Name

Nexium

Common Name

esomeprazole

In this drug factsheet:

DIN (Drug Identification Number)

02244521 NEXIUM 20MG TABLET
02244522 NEXIUM 40MG TABLET
02300524 NEXIUM 10MG SACHET

How does this medication work? What will it do for me?

Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). In adults and children, it is used to treat conditions such as reflux esophagitis (tissue damage caused by stomach contents flowing back up the esophagus) and symptoms of gastroesophageal reflux disease (GERD) in people with reflux esophagitis. It is also used to treat nonerosive reflux disease (NERD; heartburn and regurgitation not related to tissue damage) in children and adults. When combined with other medications, esomeprazole is used to treat duodenal ulcers that are caused by bacteria known as H. pylori.

Esomeprazole can be used to treat or reduce the risk of stomach ulcers due to medications known as NSAIDs (e.g., ibuprofen, naproxen, ketorolac) that irritate the stomach. It is also used to treat conditions associated with the overproduction of stomach acid, including Zollinger-Ellison syndrome.

Esomeprazole works by reducing the amount of acid the stomach produces.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The recommended dose of esomeprazole to treat reflux esophagitis and symptoms of GERD is 40 mg once daily for 4 to 8 weeks. After 8 weeks, treatment may be continued at a dose of 20 mg once daily.

To treat NERD or heartburn, the recommended does is 20 mg taken once daily for 2 to 4 weeks. After this, esomeprazole may be taken at a dose of 20 mg once daily as needed to control symptoms.

To treat stomach ulcers associated with NSAID use, the dose is 20 mg once daily for 4 to 8 weeks. To prevent such ulcers, the dose is 20 mg once daily.

To treat duodenal ulcers caused by H. pylori in adults, the dose of esomeprazole is 20 mg twice daily taken with amoxicillin 1,000 mg twice daily and clarithromycin 500 mg twice daily - all for 7 days.

For children 12 months to 11 years of age, the recommended dose of esomeprazole to treat reflux esophagitis is 10 mg to 20 mg (depending on the child's weight) once daily for 8 weeks. For NERD (heartburn and reflux), the recommended dose is 10 mg once daily for up to 8 weeks.

For children 11 to 17 years of age, the recommended dose of esomeprazole to treat reflux esophagitis is 20 mg to 40 mg once daily for 4 to 8 weeks. For NERD (heartburn and reflux), the recommended dose is 20 mg once daily for 2 to 4 weeks.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Esomeprazole tablets can be taken with or without food. They should be swallowed whole - do not crush or chew them. Alternatively, the tablet may be stirred into half a glass of noncarbonated water until it disintegrates. Drink the liquid containing the small pellets of medication immediately, or within 30 minutes. To ensure you get the full dose of the medication, rinse the glass with more water and drink it.

The sachets of esomeprazole contain granules for oral suspension. Pour all the granules of one sachet into a glass containing one tablespoon (15 mL) of water, stir, and leave for a few minutes to allow the mixture to thicken. Stir again and drink it within 30 minutes. To ensure you get the full dose of the medication, rinse the glass with more water and drink it.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

Tablets

20 mg
Each light pink, oblong, and biconvex, delayed-release tablet, engraved with "20 mg" on one side and "A" over "EH" on the other side, contains esomeprazole 20 mg equivalent to esomeprazole magnesium trihydrate 22.3 mg. Nonmedicinal ingredients: cellulose microcrystalline, crospovidone, glyceryl monostearate, hydroxypropyl cellulose, hypromellose, iron oxide, magnesium stearate, methacrylic acid ethylacrylate copolymer, polyethylene glycol, polysorbate, sodium stearyl fumarate, sugar spheres, synthetic paraffin, talc, titanium dioxide, and triethyl citrate.

40 mg
Each pink, oblong, and biconvex, delayed-release tablet, engraved with "40 mg" on one side and "A" over "EI" on the other side, contains esomeprazole 40 mg equivalent to esomeprazole magnesium trihydrate 44.5 mg. Nonmedicinal ingredients: cellulose microcrystalline, crospovidone, glyceryl monostearate, hydroxypropylcellulose, hypromellose, iron oxide, magnesium stearate, methacrylic acid ethylacrylate copolymer, polyethylene glycol, polysorbate, sodium stearyl fumarate, sugar spheres, synthetic paraffin, talc, titanium dioxide, and triethyl citrate.

Sachet (granules) for oral suspension

Each sachet of fine pale yellow (may also be brownish) delayed release granules contains 10 mg of esomeprazole. Nonmedicinal ingredients: dextrose, crospovidone, citric acid, glycerol monostearate, hypromellose, hydroxypropyl cellulose, iron oxide, magnesium stearate, methacrylic acid copolymer type C, polysorbate, sugar spheres, talc, triethyl citrate, and xanthan gum.

Who should NOT take this medication?

Do not take this medication if you are allergic to esomeprazole or any ingredients of the medication.

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • abdominal pain
  • constipation
  • diarrhea
  • dizziness
  • drowsiness
  • dry mouth
  • gas
  • headache
  • nausea
  • trouble sleeping

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • blurred vision
  • confusion
  • sensitivity to the sun
  • shortness of breath
  • signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • skin reactions (such as rash, itching, or hives)
  • sore joints

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • severe skin problems (blisters, ulcers or lesions)
  • signs of a severe allergic reaction such as hives; difficulty breathing; or swelling of the tongue, face, mouth, or throat

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are any nutrients depleted by this medication?

Some medications can affect vitamin and nutrient levels in the body. Below is a list of nutrient depletions associated with this medication. Talk to your doctor or pharmacist about whether taking a supplement is recommended or if you have any questions or concerns.

Nexium may deplete vitamin B12

How can this nutrient deficiency impact me?
Vitamin B12, also known as cyancobalamin or cobalamin, is involved in the body's metabolism, DNA synthesis, and red blood cells. It also helps maintain the nervous system. Vitamin B12 deficiency is most common in people on meatless diets since it is not found in grains, fruits, or vegetables. Talk to your Rexall™ Pharmacist about vitamin B12 deficiency. Vitamin B12 is available as a supplement, such as Be Better Vitamin B12. Before starting any nutrient supplement, always talk with your Rexall™ Pharmacist.

Nexium may deplete magnesium

How can this nutrient deficiency impact me?
Magnesium is a nutrient important to the body's metabolism, energy production, and detoxification. It also is involved in the production of some hormones as well as healthy bones and teeth. Magnesium helps to control blood pressure and maintain heart health. Magnesium deficiency can increase the risk of stomach disorders, osteoporosis, high blood pressure, stroke, and heart attack. Magnesium is available in supplements such as Rexall™ Magnesium Citrate. Before starting any nutrient supplement, always talk with your Rexall™ Pharmacist.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Methotrexate interaction: Esomeprazole, like other medications in this group, may interact with methotrexate when the two medications are used at the same time. This combination may lead to higher than expected amounts of methotrexate in the body and can cause serious side effects, including kidney damage, irregular heartbeat, anemia, or infection. If you take esomeprazole and are also going to receive a dose of methotrexate, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

More serious conditions of the stomach and intestines: If you experience symptoms of a more serious condition of the stomach and intestines (e.g., trouble swallowing, unplanned weight loss, vomiting of blood or food, or black stools) while taking this medication, contact your doctor immediately.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if esomeprazole passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

What other drugs could interact with this medication?

There may be an interaction between esomeprazole and any of the following:

  • antiretroviral medications (e.g., atazanavir, delaviridine, lopinavir, nelfinavir)
  • "azole" antifungals (e.g., fluconazole, itraconazole, ketoconazole, voriconazole)
  • bisphosphonates (e.g., alendronate, etidronate, risedronate)
  • bosutinib
  • carbamazepine
  • certain benzodiazepines (e.g., alprazolam, clobazam, diazepam)
  • citalopram
  • clopidogrel
  • dabigatran
  • dasatinib
  • dextroamphetamine
  • erlotinib
  • fluoxetine
  • folic acid
  • ifosfamide
  • iron (e.g., ferrous sulfate, ferrous fumarate)
  • mesalamine
  • methotrexate
  • methylphenidate
  • moclobemide
  • multiple vitamins
  • mycophenolate
  • nilotinib
  • omeprazole
  • phenobarbital
  • phenytoin
  • rifampin
  • sertraline
  • "statin" cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
  • St. John's wort
  • tacrolimus
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material © 2013-2014 MTPkits Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

 

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